Tratamiento de las quemaduras oculares por productosquímicos mediante aplicación tópica y subconjuntival deplasma rico en factores regeneradores. Estudio comparativo / Topical vs subconjunctival application of regenerative factor-rich plasma for chemical eye burns: a comparative study

Estudio de la aplicación subconjuntival y tópica de plasma rico en factores regeneradores(PRFR) en pacientes con quemaduras oculares por productos químicos. Se analizaron15 ojos de 15 pacientes con quemaduras químicas oculares. Se dividieron en tres grupos: uno de control con tratamiento médico clásico; otro con tratamiento médico clásico y tópico de PRFR y un tercero, con tratamiento médico clásico e infiltración subconjuntivalde PRFR. Se estudió la evolución clínica de las lesiones y tiempo hasta su curación final. En los grupos con PRFR tópico y subconjuntival hubo un acortamiento de los días de curación frente al grupo control, que fueron significativos para las variables tiempo de curación final, epitelización de córnea y conjuntiva. Podemos considerarla aplicación tópica y subconjuntival de RFRP como un tratamiento eficaz, sencillo y económico en el tratamiento de las causticaciones de la superficie ocular (AU)

We assess the efficacy of subconjunctival and topical application of regenerative factor-rich plasma (RFRP) for chemical eye burns. Fifteen eyes with chemical burns in 15 patients distributed in 3 groups were treated. One group received routine care (control group), another received routine care plus topical RFRP application, and another received routine care plus subconjunctival RFRP application. Clinical course and time until definitive cure. Were analyzed times until a definitive cure and corneal and conjunctival epithelization in the groups receiving RFRP application (either topical or subconjunctival) were shorter than the times in the control group. We conclude that RFRP application, whether topical or subconjunctival, is an effective, uncomplicated, and economical treatment for eye burns from caustic chemicals (AU)

[Distribution of met-enkephalin expression in the visual pathway. Experimental study by inmunocytochemistry]. / Distribución de la metencefalina en la vía óptica. Estudio experimental inmunocitoquímico.

PURPOSE: The localization and distribution of neuropeptide expression in the cat visual pathway can provide information about the function of that pathway. METHOD: Study of optic pathway in eight cats. Following extraction of the brain, slices were prepared using a microkeratome. The slices were examined by indirect immunocytochemistry using anti-metenkephalin as antibody to determine the presence or absence of this pentapeptide in the visual pathway. RESULTS: Met-enkephalin receptors in both cortical and subcortical regions of the brain were detected. This suggests that met-enkephalin could be involved in the visual mechanism. CONCLUSIONS: The presence of met-enkephalin receptors in both cortical and subcortical regions of the brain suggests that this pentapeptide could be involved in the visual mechanism.

Distribución de la metencefalina en la vía óptica. Estudio experimental inmunocitoquímico / Distribution o met-enkephalin expression in the visual pathway. Experimental study by inmunocytochemstry

Objetivo: Conocer la localización y distribución deneuropéptidos en la vía óptica, concretamente, ladeterminación de inmunorreactividad a met-encefalina,clave para la funcionalidad de dicha vía.Método: Se analizó la vía óptica de ocho gatos.Tras extracción quirúrgica; cortes con microqueratomoy procesamiento mediante inmunocitoquímicaindirecta, utilizando como anticuerpo la antimetencefalina,con el fín de detectar la presencia oausencia del pentapéptido en la vía óptica del gato.Resultados: Se detectaron receptores a met-encefalinaen áreas del encéfalo tanto corticales como subcorticales.Así, se considera la posible implicaciónde dicho pentapéptido en la funcionalidad de la víaóptica.Conclusiones: La presencia de receptores a metencefalinaen áreas del encéfalo tanto corticalescomo subcorticales, muestra la posible implicaciónde dicho neurotransmisor en la funcionalidad de lavía óptica (AU)

Purpose: The localization and distribution of neuropetideexpression in the cat visual pathway can provideinformation about the function of that pathway.Method: Study of optic pathway in eight cats.Following extraction of the brain, slices were preparedusing a microkeratome. The slices were examinedby indirect immunocytochemistry using antimetenkephalinas antibody to determine the presenceor absence of this pentapeptide in the visualpathway.Results: Met-enkephalin receptors in both corticaland subcortical regions of the brain were detected.This suggests that met-enkephalin could be involvedin the visual mechanism.Conclusions: The presence of met-enkephalinreceptors in both cortical and subcortical regions ofthe brain suggests that this pentapeptide could beinvolved in the visual mechanism(AU)

[Subconjunctival application of plasma platelet concentrate in the treatment of ocular burns. Preliminary results]. / Aplicación subconjuntival de concentrado de plaquetas plasmáticas en el tratamiento de quemaduras oculares. Resultados preliminares.

PURPOSE: The efficiency of the subconjunctival application of autologous platelet concentrate in patients with ocular burns was assessed. METHODS: This was carried out by analysing the effect of treatment in the eyes of 10 patients suffering from ocular burns as a result of work-related accidents. Two types of treatment were evaluated: the first group only received conventional topical medical treatment; and the second group, in addition, had subconjunctival injection of plasma platelet concentrate. The clinical condition of the patient and the period in which the disease prevented the patient from working were studied; monitoring was carried out until the burns had fully healed. RESULTS: Statistically significant differences were found between the group treated with subconjunctival autologous platelet concentrate and the group treated with conventional topical medications, with a shorter period of time in corneal and conjunctival healing, time on sick leave and time needed for full healing. CONCLUSIONS: Subconjunctival infiltration of autologous platelet concentrate should be considered as a straightforward, economical and possibly effective form of treatment for traumatic accidents (burns) of the ocular surface.

Aplicación subconjuntival de concentrado de plaquetas plasmáticas en el tratamiento de quemaduras oculares. Resultados preliminares / Subconjunctival application of plasma platelet concentrate in the treatment of ocular burns. Preliminary results

Objetivo: Se valoró la eficacia de la aplicación subconjuntival de concentrado de plaquetas plasmáticas autólogas en pacientes con quemaduras oculares. Método: Para ello se analizaron 10 ojos de 10 pacientes que sufrieron accidentes laborales por quemaduras oculares del mismo grado. Se establecieron dos tipos de tratamiento: al primer grupo, control, se le aplicó tratamiento médico tópico convencional; al segundo, se le añadió además, inyección subconjuntival de concentrado de plaquetas autólogas. Se estudió la evolución clínica, días que le incapacitaron dicha patología para su actividad laboral y seguimiento hasta su curación final. Resultados: Se encontraron diferencias entre el grupo de los tratados con concentrado de plaquetas autólogas subconjuntivales respecto al grupo con tratamiento médico tópico convencional, siendo más corto el tiempo de cicatrización de córnea (significativamente estadístico), conjuntiva, baja laboral y tiempo hasta curación final. Conclusiones: Podemos considerar la autoplaquetoterapia subconjuntival (infiltración subconjuntival de concentrado de plaquetas autólogas) como un tratamiento sencillo y económico en el tratamiento de las alteraciones traumáticas (quemaduras) de la superficie ocular. Cuya eficacia deberá ser confirmada por series mayores

Purpose: The efficiency of the subconjunctival application of autologous platelet concentrate in patients with ocular burns was assessed. Methods: This was carried out by analysing the effect of treatment in the eyes of 10 patients suffering from ocular burns as a result of work-related accidents. Two types of treatment were evaluated: the first group only received conventional topical medical treatment; and the second group, in addition, had subconjunctival injection of plasma platelet concentrate. The clinical condition of the patient and the period in which the disease prevented the patient from working were studied; monitoring was carried out until the burns had fully healed. Results: Statistically significant differences were found between the group treated with subconjunctival autologous platelet concentrate and the group treated with conventional topical medications, with a shorter period of time in corneal and conjunctival healing, time on sick leave and time needed for full healing. Conclusions: Subconjunctival infiltration of autologous platelet concentrate should be considered as a straightforward, economical and possibly effective form of treatment for traumatic accidents (burns) of the ocular surface

[Ocular hypertension in children treated with brimonidine 0.2%. A clinical study]. / Tratamiento de la hipertensión ocular infantil con colirio de brimonidina 0,2%.

PURPOSE: To evaluate the safety and efficacy of topical brimonidine 0.2% use in children. MATERIALS AND METHODS: A descriptive study of twelve successive children (21 eyes) who needed topical treatment of intraocular hypertension, and where the use of b-blockers was contraindicated. RESULTS: During treatment we observed an average decrease of IOP of 5 SD 1.8 mmHg (21% of basal IOP), but found more common local symptoms, with stinging being complained of in 52.4% of cases. Somnolence was also complained of in two cases.

Tratamiento de la hipertensión ocular infantil con colirio de brimonidina 0.2% / Ocular hypertension in children treated with brimonidine 0.2%. A clinical study

Objetivos: Se ha valorado la seguridad y eficaciade uso del colirio de brimonidina 0,2% en niños.Método: Se estudiaron doce niños con hipertensiónocular (21 ojos) y contraindicación del uso de betabloqueantes.Se realiza estudio descriptivo de casossucesivos de niños que necesitaban tratamientomédico tópico por hipertensión ocular.Resultados: En cuanto a la eficacia del tratamientose observa un descenso medio de la PIO de 5 DE1,8 mmHg (21% de la PIO basal) y en cuanto a laseguridad en el uso del medicamento se encontrócon síntomas más frecuentes a nivel local el escozoren un 52,38% de los casos y a nivel sistémico laaparición de somnolencia en dos casos

Purpose: To evaluate the safety and efficacy of topical brimonidine 0.2% use in children. Materials and methods: A descriptive study of twelve successive children (21 eyes) who needed topical treatment of intraocular hypertension, and where the use of b-blockers was contraindicated. Results: During treatment we observed an average decrease of IOP of 5 SD 1.8 mmHg (21% of basal IOP), but found more common local symptoms, with stinging being complained of in 52.4% of cases. Somnolence was also complained of in two cases